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PI3K/AKT/mTOR signaling in gastric cancer: Epigenetics and beyond.
Fattahi S, Amjadi-Moheb F, Tabaripour R, Ashrafi GH, Akhavan-Niaki H. Fattahi S, et al. Among authors: akhavan niaki h. Life Sci. 2020 Dec 1;262:118513. doi: 10.1016/j.lfs.2020.118513. Epub 2020 Oct 1. Life Sci. 2020. PMID: 33011222 Review.
In this review, we focused on the role of this pathway in gastric cancer development, prognosis, and metastasis, with an emphasis on epigenetic alterations including DNA methylation, histone modifications, and post-transcriptional modulations through non-coding RNAs fluctuations …
In this review, we focused on the role of this pathway in gastric cancer development, prognosis, and metastasis, with an emphasis on epigene …
Ninety-six-hour starved peripheral blood mononuclear cell supernatant inhibited LA7 breast cancer stem cells induced tumor via reduction in angiogenesis and alternations in Gch1 and Spr expressions.
Mehri M, Gheitasi R, Pourbagher R, Ranaee M, Nayeri K, Rahimi SM, Khorasani HR, Hossein-Nattaj H, Sabour D, Akhavan-Niaki H, Fattahi S, Kalali B, Mostafazadeh A. Mehri M, et al. Among authors: akhavan niaki h. Front Immunol. 2023 Feb 23;13:1025933. doi: 10.3389/fimmu.2022.1025933. eCollection 2022. Front Immunol. 2023. PMID: 36908807 Free PMC article.
METHOD: Ninety-six-hour starved PBMCs supernatant (96 h-SPS) was collected after culturing human PBMCs for 96 h under serum starvation condition. ...Last, proteomics analysis revealed candidate effectors' components of 96 h-SPS solution. CONCLUSION: 96 h …
METHOD: Ninety-six-hour starved PBMCs supernatant (96 h-SPS) was collected after culturing human PBMCs for 96 h under serum st …
Targeting LA7 breast cancer stem cells of rat through repressing the genes of stemness-related transcription factors using three different biological fluids.
Pourbagher R, Akhavan-Niaki H, Jorsaraei SGA, Fattahi S, Sabour D, Zabihi E, Abedian Z, Ghasemi M, Golpour M, Mostafazadeh A. Pourbagher R, et al. Among authors: akhavan niaki h. Gene. 2020 Apr 15;734:144381. doi: 10.1016/j.gene.2020.144381. Epub 2020 Jan 21. Gene. 2020. PMID: 31978510
The aim of this study was to evaluate the Oct4 , Sox2, Nanog, and C-myc expression in rat breast cancer stem cells (LA7) which treated with human ovarian follicular fluid (FF), replicative senescent fibroblast culture supernatant (P14), and 16 h serum starved fibroblast su …
The aim of this study was to evaluate the Oct4 , Sox2, Nanog, and C-myc expression in rat breast cancer stem cells (LA7) which treated with …
CTNNBIP1 downregulation is associated with tumor grade and viral infections in gastric adenocarcinoma.
Kosari-Monfared M, Nikbakhsh N, Fattahi S, Ghadami E, Ranaei M, Taheri H, Amjadi-Moheb F, Godazandeh GA, Shafaei S, Pilehchian-Langroudi M, Samadani AA, Akhavan-Niaki H. Kosari-Monfared M, et al. Among authors: akhavan niaki h. J Cell Physiol. 2019 Mar;234(3):2895-2904. doi: 10.1002/jcp.27106. Epub 2018 Aug 4. J Cell Physiol. 2019. PMID: 30076728
In the absence of EBV infection, lower expression of CTNNBIP1 was observed. There was no association between H. pylori infection and CTNNBIP1 expression. Our findings revealed the tumor suppressor role for CTNNBIP1 in gastric adenocarcinoma. ...
In the absence of EBV infection, lower expression of CTNNBIP1 was observed. There was no association between H. pylori infection and …
Epigenetic alterations of CYLD promoter modulate its expression in gastric adenocarcinoma: A footprint of infections.
Ghadami E, Nikbakhsh N, Fattahi S, Kosari-Monfared M, Ranaee M, Taheri H, Amjadi-Moheb F, Godazandeh G, Shafaei S, Nosrati A, Pilehchian Langroudi M, Samadani AA, Amirbozorgi G, Mirnia V, Akhavan-Niaki H. Ghadami E, et al. Among authors: akhavan niaki h. J Cell Physiol. 2019 Apr;234(4):4115-4124. doi: 10.1002/jcp.27220. Epub 2018 Aug 21. J Cell Physiol. 2019. PMID: 30132887
Also, we investigated the impacts of the infectious agents including Helicobacter pylori (H. pylori), EBV, and CMV on CYLD expression and promoter methylation in GC. ...We also found a significant inverse association between DNA promoter methylation and CYLD expression (p …
Also, we investigated the impacts of the infectious agents including Helicobacter pylori (H. pylori), EBV, and CMV on CYLD expression …
First comprehensive computational analysis of functional consequences of TMPRSS2 SNPs in susceptibility to SARS-CoV-2 among different populations.
Paniri A, Hosseini MM, Akhavan-Niaki H. Paniri A, et al. Among authors: akhavan niaki h. J Biomol Struct Dyn. 2021 Jul;39(10):3576-3593. doi: 10.1080/07391102.2020.1767690. Epub 2020 Jun 1. J Biomol Struct Dyn. 2021. PMID: 32410502 Free PMC article.
Also, this study could pave the way to potential therapeutic implication of TMPRSS2 in designing antiviral drugs.Communicated by Ramaswamy H. Sarma....
Also, this study could pave the way to potential therapeutic implication of TMPRSS2 in designing antiviral drugs.Communicated by Ramaswamy …
Downregulation of Stemness Genes and Induction of Necrosis in Rat LA7 Cancer Stem Cells Induced Tumors Treated with Starved Fibroblasts Culture Supernatant.
Pourbagher R, Ghorbani H, Akhavan-Niaki H, Jorsaraei SGA, Fattahi S, Ghooran S, Abedian Z, Ghasemi M, Saeedi F, Jafari N, Kalali B, Mostafazadeh A. Pourbagher R, et al. Among authors: akhavan niaki h. Rep Biochem Mol Biol. 2021 Apr;10(1):105-118. doi: 10.52547/rbmb.10.1.105. Rep Biochem Mol Biol. 2021. PMID: 34277874 Free PMC article.
Then the tumors were removed and divided into the two parts, one part was used to quantify gene expression by stem-loop RT-qPCR assay and the other part was used for Hematoxylin & Eosin (H & E), Giemsa, and immunohistochemistry (IHC) staining. RESULTS: All induced …
Then the tumors were removed and divided into the two parts, one part was used to quantify gene expression by stem-loop RT-qPCR assay and th …
Prevalence of multiple infections and the risk of gastric adenocarcinoma development at earlier age.
Fattahi S, Nikbakhsh N, Taheri H, Ghadami E, Kosari-Monfared M, Amirbozorgi G, Asouri M, Pilehchian-Langroudi M, Ranaee M, Samadani AA, Paryan M, Akhavan-Niaki H. Fattahi S, et al. Among authors: akhavan niaki h. Diagn Microbiol Infect Dis. 2018 Sep;92(1):62-68. doi: 10.1016/j.diagmicrobio.2018.04.015. Epub 2018 May 11. Diagn Microbiol Infect Dis. 2018. PMID: 29880208
Furthermore, CMV frequency in tumoral tissues (68.75%) was significantly higher than in nontumoral tissues (12.5%) (P = 0.0311). Although H. pylori infection was significantly lower in tumoral tissues than in nontumoral tissues (P = 0.0136), all tumoral tissues had cagA, w …
Furthermore, CMV frequency in tumoral tissues (68.75%) was significantly higher than in nontumoral tissues (12.5%) (P = 0.0311). Although …
Human PBMCs fight or flight response to starvation stress: Increased T-reg, FOXP3, and TGF-β1 with decreased miR-21 and Constant miR-181c levels.
Rahmani M, Mohammadnia-Afrouzi M, Nouri HR, Fattahi S, Akhavan-Niaki H, Mostafazadeh A. Rahmani M, et al. Among authors: akhavan niaki h. Biomed Pharmacother. 2018 Dec;108:1404-1411. doi: 10.1016/j.biopha.2018.09.163. Epub 2018 Oct 6. Biomed Pharmacother. 2018. PMID: 30453448 Free article.
Herewith, we have examined the in vitro effects of serum starvation for 16, 48, 72 and 96 h on the expression of T-reg differentiation markers (CD4, CD25, CD127, and FOXP3) as well as on the Transforming Growth Factor-beta1 (TGF-beta1) and some microRNAs (miR-21,-29a,-31,1 …
Herewith, we have examined the in vitro effects of serum starvation for 16, 48, 72 and 96 h on the expression of T-reg differentiatio …
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